Nutrafortified ®

"Eat Healthy, Be Active and Live Long Enjoyable Lives!"

Published Scientific Research:

1) Fleming, J., Ghose, A., & Harrison, P. R., (2001). Molecular mechanisms of cancer prevention by selenium compounds. Nutrition and Cancer, 40, 42–49.

2) Reilly, C. (2006). Selenium in health and disease III: Nonendemic selenium-responsive conditions, cancer, and coronary vascular disease. In Selenium in Food and Health, Second Edition. (pp.111-133). Springer US: DOI. 10.1007/978-0-387-33244-4_6

3) Palevitch, D., Earon, G., Hevir, I. (1993). Treatment of benign prostate hypertrophy with Opuntia ficus indica (L.) Miller. Journal of Herbs, Spices and Medicinal Plants, 2, 45-49.

4) Schwarz, K. and C.M. Folz. (1957). Selenium as an integral part of Factor 3 against dietary necrotic liver degeneration. Journal American Chemical Society 78, 3292.

5) Reid, M., Duffield-Lillico, A.J., Garland, L., Turnbull, B.W., Clark, L.C., & Marshall, J.R. (2002). Selenium supplementation and lung cancer incidences: an update of the nutritional prevention cancer trial. Cancer Epidemiological Biomarkers Preview, 11, 1285-1291.

6) Tsai, C., Ou, B., Liang, Y., & Yeh, J. (2013). Growth inhibition and antioxidative status induced by selenium-enriched broccoli extract and selenocompounds in DNA mismatch repair-deficient human colon cancer cells. Food Chemistry, 139, 267–273.

7) Zhao, R., Domann, F.E., & Zhong, W. (2006). Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Molecular Cancer Therapeutics 5, 3275-3284.

8) Combs GF, Jr and Gray WP. Chemopreventive agents: Selenium. Pharmacological Therapy 1998; 79,179-92.

9) Bãnuelos, G.S., Fakra, S.C., Walse, S.S., Matthew A. Marcus, M.A., Yang, S-I., Pickering, I.J., Pilon-Smits, E.A.H., & Freeman, J.L. (2011). Selenium accumulation, distribution and speciation in spineless prickly pear cactus: a drought and salt tolerant, Se enriched nutraceutical fruit crop for biofortified foods. Plant Physiology, 155, 315-327.

10) Zou, D.M., Brewer, M., Garcia, F., Feugang, J.M., Wang, J., Zang, R., Liu, H., & Zou, C.P. (2005). Cactus pear- a natural product in cancer chemoprevention. Nutrition Journal, 4:25, doi:10.1186/1475-2891-4-25

11) Butera, D., Tesoriere, L., Di Gaudio, F., Bongiorno, A., Allegra, M., Pintaudi, A.M., Kohen, R., & Livrea, M.A. (2002). Antioxidant Activities of Sicilian Prickly Pear (Opuntia ficus indica) Fruit Extracts and Reducing Properties of Its Betalains: Betanin and Indicaxanthin. Journal of Agricultural and Food Chemistry, 50, 6895–6901.

12) Bãnuelos, G.S., Stushnoff C., Walse, S.S., Zuber T., & Freeman, J.L. (2012) Bio-fortified, selenium enriched, fruit and cladode from three Opuntia Cactus pear cultivars grown on agricultural drainage sediment for use in nutraceutical foods. Food Chemistry, 135, (1) 9-16.

13) McKenzie RC, Rafferty TS, Beckett GJ. (1998) Selenium: an essential element for immune function. Immunology Today 19,342-5.

14) Clark, L.C., G.F. Combs, Jr., B.W. Turnbull, E. Slate, D. Alberto, D. Abele, R. Allison, J. Bradshaw, D. Chelker, J. Chow, D. Curtis, J. Dalen, L. Davis, R. Deal, M. Dellasega, R. Glover, G. Graham, E. Gross, J. Hendrix, J. Herlong, F. Knight, A. Krongrad, J. Desher, J. Moore, K. Park, J. Nice, A. Rudgers, B. Sanders, C. Smith, E. Smith, J. Taylor and J. Woodward. 1997. The nutritional prevention of cancer with selenium, 1983-1993; a randomized, clinical trial. Journal of American Medical Association 276 .

15) Ip, C., Lisk, D.J., & Stoews, G.S. (1992) Mammary cancer prevention by regular garlic and selenium-enriched garlic. Nutrition Cancer, 17, 279-286.

16)  Clark, L.C., Combs, G.F., Turnbull, B.W., Slate, E.H., Chalker, D.K., Chow, J., Davis, L.S., Glover, R.A., Graham, G.F., & Gross, E.G. (1996). Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. Journal of American Medical Association, 276, 1957-1963.

17) Combs, G.F. (2000). Food system-based approaches to improving micronutrient nutrition: the case for selenium. Biofactors, 12, 39-43.

18) Bãnuelos, G.S., Walse, S.S.,  Yang, S.I., Pickering, I.J., Fakra, SC Marcus MA, & Freeman, J.L. (2012) Quantification, localization and speciation of selenium in seeds of canola and two mustard species compared to seed-meals produced by hydraulic press. Analytical Chemistry, 84: (14), 6024–6030.

19) Dok-Go, H., Lee, K.H., Kim, K.H.,  Lee, E.H., Lee, J., Song, Y.S., Lee, Y.H., Jin, C., Lee, Y.S., & Cho, J. (2003). Neuroprotective effects of antioxidative flavonoids,quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus indica var. saboten. Brain Research, 965, 130-136.

20) Ellis DR, Salt DE (2003) Plants, selenium and human health. Current Opinions Plant Biology, 6, 273–279.

21) Kobayashi K, Yamazaki C, Suzuki K, Murakami M, Koyama H. (2009) Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. Bio Med Central Cancer. 30;9:414.

22) Finley,J.W., Ip, C., Lisk, D.J., Davis, C.D., Hintze, K.J., & Whanger, P.D. (2001). Cancer-Protective Properties of High-Selenium Broccoli.Journal of Agricultural and Food Chemistry, 49, 2679-2683.

23) Finley, J.W., Sigrid-Keck, A., Robbins, R.J., Hintze, K.J. (2005) Selenium enrichment of broccoli: interactions between selenium and secondary plant compounds. The Journal of nutrition, 135, 1236-1238.

24) Finley, J.W., Davis, C.D., & Feng, Y. (2000). Selenium from high selenium broccoli protects rats from colon cancer. Journal of Nutrition, 130, 2384-2389.

25) Feugang, J.M., Konarski, P., Zou, D., Stintzing, F.C., & Zou, C. (2006). Nutritional and medicinal use of cactus pear Opuntia spp. cladodes and fruit. Frontiers in Bioscience, 11, 2574-2589.

26) Finley, J.W. (2006). Bioavailability of selenium from foods. Nutrition Reviews, 64, 146-151.

27) Galvis Sanchez, A.C., Gil-Izquierdo, A., Gil, M.I. (2003). Comparative study of six pear cultivars in terms of their phenolic and ascorbic acid contents and antioxidant capacity. Journal of the Science of Food and Agricultutre, 83, 995–1003.

28) Hegwood, D.A. (1990). Human health discoveries with Opuntia sp. (prickly pear). Horticulture Science 25, 1515-1516.

29) Ip, C., & Ganther, H.E. (1992). Relationship between the chemical form of selenium and anticarcinogenic activity. In I. Wattenberg, M. Lipkin, CW. Boon, GJ. Kellott (Eds.), Cancer Chemoprevention (pp 479-488). Boca Raton, FL: CRC Press.

30) Kuti, J.O. (2004) Antioxidant compounds from four Opuntia cactus pear fruit varieties. Food Chemistry 85, 527-533.

31) Lee, S.A., Fowke, J.H., Lu, W., Ye, C., Zheng, Y., Cai, Q., Gu, K., Gao, Y.T., Shu, X.O., & Zheng, W. (2008) Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk. American Journal of Clinical Nutrition, 87, 753-60.

32) Kuti, J.O. (2004) Antioxidant compounds from four Opuntia cactus pear fruit varieties. Food Chemistry  85, 527-533.

33) Levander OA. (1997) Nutrition and newly emerging viral diseases: An overview. Journal Nutrition 127, 948-950.

34) Arthur JR. (1991) The role of selenium in thyroid hormone metabolism. Canadian Journal Physiology Pharmacology 69, 1648-1652.

35) Corvilain B, Contempre B, Longombe AO, Goyens P, Gervy-Decoster C, Lamy F, Vanderpas JB, Dumont JE. (1993) Selenium and the thyroid: How the relationship was established. American Journal of Clinical Nutrition  57 (2 Suppl):244-248.

36) Kuroki F, Matsumoto T, Lida M. (2003) Selenium is depleted in Crohn's disease on enteral nutrition. Digestive Diseases 21, 266-270.

37) Rannem T, Ladefoged K, Hylander E, Hegnhoj J, Jarnum S. (1992) Selenium status in patients with Crohn's disease. American Journal Clinical Nutrition 56, 933-937.

38) Frati, A.C., Jimenez, E., & Ariza, C.R. (1990). Hypoglycemic effect of Opuntia ficus indica in non insulin-dependent diabetes mellitus patients. Phytotherapy Research, 4, 195-197.

39) Bjerre B, von Schenck H, Sorbo B. (1989) Hyposelaemia: Patients with gastrointestinal diseases are at risk. Journal Internal Medicine 225, 85-88.

40) Gartner R, Albrich W, Angstwurm MW. (2001) The effect of a selenium supplementation on the outcome of patients with severe systemic inflammation, burn, and trauma. BioFactors 14, 199-204.

41) Cindy D. Davis, Huawei Zeng and John W. Finley 2002. Selenium-Enriched Broccoli Decreases Intestinal Tumorigenesis in Multiple Intestinal Neoplasia Mice. Journal of Nutrition 132, 307-309.

42) Clark, L.C., Cantor, K.P., Allaway, W.H. (1991). Selenium in forage crops and cancer mortality in US counties. Archives Environmental Health 46, 37-42.

43) Levander, O.A. and M.A. Beck. (1996) Viral evolution as driven by host nutritional selective factors: Influence of dietary oxidative stress. Food Chemistry. 57, 47.

44) Chen, X.S., G.L. Yang, J.O. Chen, X.C. Chen, Z.M. Wen and K.Y. Ge. 1980. On the relations of selenium and Keshan disease. Biology. Trace Element Research. 2, 91.

45) Moreno-Reyes, R., Suetens, C., Mathieu, F., Begaux, F., Zhu, D., Rivera, M.T., Boelaert, M., Neve, J., Perlmutter, N., & Vanderpas, J. (1998) Kashin-Beck Osteoarthropathy in Rural Tibet in Relation to Selenium and Iodine Status. New England Journal of Medicine, 339, 1112-1120.

46) Muth, O.H., J.E. Oldfield, L.F. Remmert and J.R. Schubert. (1958) Effects of selenium and vitamin E on white muscle disease. Science 128, 1090.

47) Oldfield, J.E. (1999) Selenium in human health. Technology 6, 157.

48) Robbins, R.J., Keck, A.S., Banuelos, G.S., & Finley J.W. (2005). Cultivation conditions and Se fertilization alter the phenolic profile and sulfuraphane content of broccoli. Journal of Medicinal Food, 8, 204-214.

49) Rotruck, J.T., W.G. Hoekstra and A.L Pope. (1971) Glucose-dependent protection by dietary selenium against hemolysis of rat erythrocytes in vitro. Nature. 231:223.

50) Schrauzer, G.N., White, D.A., Schneider, C.J. (1977) Cancer mortality correlation studies, III. Bioinorganic Chemistry 7, 23-34.

51)  Spallholz, J.E., Shriver, B.J., & Reid, T.W. (2001) Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine. Nutrition Cancer, 40, 34-41.

52) Stadtman, T.C. (1980). Selenium-dependent enzymes. Annual Review Biochemistry, 49, 93-110.

53) Whanger, P.D. (2002). Selenocompounds in plants and animals and their biological significance. Journal of the American College of Nutrition, 21, 223-232.

54) Yeh, J-Y.,  Ou, B-R., Liang Y-C., Burchfiel, J., Butler, J.A., Forsberg, N.E., Whanger, P.D. (2006) Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells. BioMetals 19, 611–621.

55) Young, R., Nahapetian, A., & Janhorbani, M. (1982). Selenium bioavailability with reference to human nutrition. The American Journal of Clinical Nutrition, 35, 1076-1088.